ABSTRACT
Background and Purpose: according to the studies that have been conducted so far, the corona virus has more severe clinical consequences in diabetic patients than in non-diabetic cases;Therefore, the present study was conducted with the aim of investigating the severity of the disease and mortality in patients infected with the Coronavirus between these 2 groups. Materials and Methods: In this cross-sectional-analytical study, the clinical records of 185 hospitalized patients with a positive laboratory diagnosis of Covid-19 were reviewed from February 14 to February 26, 2020. The patients were divided into 2 non-diabetic (95 people) and diabetic (90 people) groups, and their clinical symptoms and blood biochemical parameters were compared. Results: Based on the results, most of the patients were male and compared to non-diabetic patients, the diabetic group was significantly older (P=0.01). In this study, the disturbance in paraclinical factors such as d-dimer, BUN, VBG and lymphopenia in diabetic patients was significantly higher than in the control group, which indicates the need for more care in diabetic patients. Conclusion: it is suggested to follow health protocols for people with land diseases, be more careful., therefore, more extensive research with larger sample sizes is needed to achieve more accurate results. [ FROM AUTHOR] Copyright of Journal of Pharmaceutical Negative Results is the property of ResearchTrentz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
ABSTRACT
Objective The primary goal of the present study was to measure the implications of hypoxemia in COVID-19 patients with a history of coronary artery disease (CAD). Methods A systematic search of the literature published from November 1, 2019 to May 1, 2021, was conducted on PubMed/MEDLINE, Embase, and Web of Science databases. Afterwards, an observational study was designed based on the electronic health records of COVID-19 patients hospitalized in a tertiary referral hospital during the same period. A total of 179 COVID-19 cases were divided into two groups: cases with a history of CAD and percutaneous coronary intervention (CAD/PCI+, n = 89) and controls (n = 90). Clinical data were extracted from the electronic database of the hospital and statistically analyzed. Results After the application of inclusion/exclusion criteria, only three studies were deemed eligible, one of which was concerned with the impact of CAD on the all-cause mortality of COVID-19. Results from our observational study indicated that the cases were older (median age: 74 vs. 45) and more likely to develop hypoxemia (25.8% vs. 8.8%) than the controls. CAD/PCI+ was correlated with a more severe COVID-19 (11% vs. 1%). Age was a moderately significant independent predictor of increased COVID-19 severity, while hypoxemia was not. Conclusion Considering the negative impact of hypoxemia on the prognosis of COVID-19 and its higher prevalence among COVID-19 patients with underlying CAD, further research is warranted to unravel the negative effects of COVID-19 on the mechanisms of gas exchange and delivery in patients with pre-existing CAD.